Objective: To treat patients of Malaria, Trypanosomiasis (sleeping sickness and Chagas disease) and also with Leishmaniasis and Kala-azar.
For now over than 10 years our group has worked together with the Medical Chemistry Group from CSIC, which developed new drugs against neglected tropical diseases, also in collaboration with a Glasgow University group and another in Switzerland (which are the project’s strategic partners). Once the way of action of the new drugs is identified (essays made in Glasgow and UPC), low toxicity tested and effectiveness proven (Switzerland group), the new drugs should be studied by a Pharmaceutical Laboratory who will distribute them at a low cost.
The scope of the project is wide and it covers regions of Africa, America and Europe.
Our specific target at the UPC group is to study the complex between the new drug and the DNA by crystallography methods, using the Synchrotron ALBA at Barcelona. In this way, we will determine at atomic level the 3D structure of the complex. It will also contribute to determine the exact way of action of the new drugs. The new drugs are synthesized with the idea of being more soluble and less toxic, in this way they are more effective and easy to administer. Finally to be accessible in price to all patients from disadventaged countries, they have been left free of patent.
World Health Organization maps and data explain the endemic areas around the world for Malaria, Trypanosomiasis and Leishmaniasis. Recently, with migration and climate change, an increase is being detected in Europe as well as in areas in America where it was not present before, such as the North of Mexico and the south of the United States. The continuity of the Project once the drugs are determined by their potential and low toxicity, the distribution and other studies will be in charge of the pharmaceutical laboratory.
Last publications from the Macrom group (UPC-BarcelonaTech):
-Acosta-Reyes F.J. et al ActaCryst.D70, 1614-1621 (2014) (Front Cover selected)
• New drug against malaria effective: Uses synchrotron light / Science Daily/ 21/07/14
• Researchers from the UPC, the CSIC and the University of Glasgow prove the effectiveness of a new drug against malaria using synchrotron light / Health Canal/ and / noodls/ 22/07/14
-Cinthia R. Millan, et al, Nucleic Acids Research, (2017) 45, 8378-8391 doi: 10.1093/nar/gkx521