Chronic obstructive pulmonary disease (COPD) is a respiratory disorder that incapacitates the patients that suffer it. It is highly prevalent and involves a significant economic and social cost. COPD is characterized by different clinical phenotypes with different risk profiles. The term phenotype in COPD is defined as those attributes of the disease that alone or combined describe the differences between individuals with COPD in relation to clinically significant parameters.
The early detection of the right phenotype, especially for those subjects who have emphysema, a type of COPD in which the lung tissue is destroyed, and the ability to predict the risk of major exacerbations, are key elements when establishing more effective treatment.
INSPIRE will develop a model that integrates the different parameters involved in COPD to better characterize the disease and be able to offer personalized treatment to the patient. Likewise, it is expected to allow optimizing the exploitation of the results obtained by Genome Wide Association, relating molecular descriptors and images and facilitating the recruitment and differentiated grouping of patients according to their characteristics.
The first project result has been a computational model simulates the clinical evolution of Chronic Obstructive Pulmonary Disease.